5 Must-Know Tips Before Taking Sildenafil 100mg

August 5, 2024

Sildenafil is a rockstar pill when it comes to managing ED, and it isn’t just because it was the very first on the scene.

Approved for use back in 1998, this medication — otherwise known as the active ingredient in Viagra — is one of the first names you’re likely to come across if you’re one of the millions of adult men who either live with ED or suspect you may have it.

Like other medications, sildenafil citrate comes in several doses, ranging from as little as 25 mg a tablet (20 mg when referring to the generic version of Revatio — a medication for a type of high blood pressure in the lungs) to as much as 100mg. The dosage you’ll be prescribed by your healthcare provider will likely be tailored to your needs based on the severity of your ED symptoms.

Below, we’ve explained what sildenafil is, as well as how it functions for the treatment of ED. We’ve also discussed:

Whether 100 mg sildenafil is safe to take
How effective 100 mg sildenafil is
How long it takes to kick in
Side effects to watch out for

Let’s dive into how you can take this medication for optimal results.

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Is it Okay to Take 100mg of Sildenafil?

Currently, 100mg is the highest dose of sildenafil that’s approved by the FDA for treating ED.

It is okay to take a 100mg dose of sildenafil, but normally, you’ll only be prescribed this dosage if you still find it difficult to get hard or maintain arousal after using a lower dose of sildenafil.

Sildenafil starts working quickly — typically in one hour or less. When it’s taken as prescribed, it can provide relief from ED and lasts for approximately four hours. Better yet, it’s available as a single pill that you can use as needed before you plan to have intercourse.

Your healthcare provider may also start treatment for ED with this dosage if you have severe symptoms. For example, if it’s particularly difficult to get hard, even following large amounts of stimulation, you may start treatment with a single dose of 100mg sildenafil.

Your healthcare provider may also consider how often you are intimate. Your dosage may be adjusted if you have intercourse frequently and take sildenafil very often, or if you only take this medication once every few days for less frequent intercourse.

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How Effective is Sildenafil 100mg?

Sildenafil works well for most men with ED at any dosage, although the highest 100mg dosage produces improvements for a greater percentage of men than 50mg or 25mg.

Sildenafil has an impressive reputation for managing ED, so it’s no surprise that at its strongest dose, this delivers for the overwhelming majority of men. If you have mild or moderate ED, your healthcare provider will likely prescribe 50mg of sildenafil as your starting dose. This is the typical go-to oral dose for sildenafil, and it’s typically enough to treat ED and improve bedroom performance for most men.

In some cases, this dosage may be reduced to 25mg of sildenafil if you’re prone to side effects, or if your healthcare provider thinks that a dosage of 50mg isn’t necessary.

In clinical trials, researchers found that 82 percent of men with ED reported some improvements in ED after using sildenafil at a dosage of 100mg. The same trials found that 74 percent and 63 percent of men reported improvements with 50mg and 25mg of sildenafil, respectively.

In a separate study, participants with ED were given a starting dose of 50mg, which was later increased to 100mg. Participants found that they quickly experienced improvements in the feel of their arousal, and were able to have more satisfying intercourse using the highest dose of sildenafil when compared with the starting dose of 50mg.

A similar study supported these findings. After four weeks of receiving sildenafil at 50mg, some participants with ED had their dosage increased to 100mg for the following four weeks. While study participants showed some improvement on the initial dose of sildenafil, the quality of their arousal and general level of bedroom satisfaction went up more significantly after using 100mg of sildenafil.

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How Long Does it Take for a 100mg Sildenafil to Kick in?

Sildenafil at any dosage takes roughly 30 to 60 minutes to start working, so you should try to take it roughly an hour before intercourse. If that means slipping away into the bathroom after you’ve paid the bill or being sneaky on your way back to the car, you don’t want to take sildenafil 10 minutes before the clothes are coming off.

Sildenafil is a phosphodiesterase type 5 inhibitor, or PDE5 inhibitor. These medications work by inhibiting an enzyme and thereby expanding the blood vessels that transport blood to your member.

One important feature of PDE5 inhibitors is that they only cause arousal when you’re feeling in the mood. Contrary to popular belief, they won’t cause spontaneous arousal (assuming you aren’t thinking about something intimate) or affect your bedroom drive in any significant way.

This means that if you aren’t aroused, sildenafil won’t “kick in” at all. Sad face.

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How to Take Sildenafil 100mg

One of the biggest advantages of sildenafil is that it’s an easy medication to use. For the most part, sildenafil can be taken before intercourse without any major concerns. However, there are a few things that you can do to get the best results from it. Try to:

Take sildenafil 100mg around one hour before intercourse. Sildenafil usually takes about a half hour to start working, but for optimal results, take your prescribed dose of sildenafil an hour before the time you plan to get intimate.
Avoid high-fat meals while using sildenafil. Eating a meal high in fat may slow down your body’s absorption of sildenafil and delay its effects. Try to eat a normal meal with a low-to-moderate fat content to ensure sildenafil works as expected.
Don’t panic if sildenafil isn’t effective the first time. A variety of factors can play a role in ED, and performance anxiety is one of them. Continue to use it and tell your healthcare provider if you don’t notice improvements over time.
Combine sildenafil with healthy habits. Simple habits such as exercising often, eating a balanced diet and limiting your alcohol intake can all have a positive effect on arousal and bedroom performance.
Try to lead a healthy lifestyle. This guide to maintaining arousal naturally shares 14 techniques that you can use to reduce your risk of ED and enjoy better intercourse.

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Sildenafil 100mg Side Effects

Most side effects of sildenafil are mild in nature and it’s uncommon for them to persist for longer than the medication is active in your body. However, in rare cases, sildenafil treatment could also cause more severe or bothersome side effects.

Sildenafil side effects are generally mild and fade over time, but they occur more frequently at 100mg than 25mg and 50mg, respectively.

For example, in clinical trials of sildenafil, 28 percent of men reported headache (by far the most common side effect) at a dosage of 100mg, compared to just 16 percent of men who used 25mg and 21 percent of men who used 50mg of sildenafil.

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Common Side Effects of Sildenafil 100mg

Common side effects of sildenafil include:

Headache
Flushing
Dyspepsia (indigestion)
Vision changes (blurred vision or changes in color perception)
Nasal congestion
Myalgia (muscle pain)
Back pain
Skin rash
Nausea
Dizziness

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Rare Side Effects of Sildenafil 100mg

Although rare, sildenafil can also cause more serious side effects, including some that may need immediate medical attention. Severe side effects include:

Eye problems like blurred vision or sudden severe loss of vision
Sudden hearing loss

In very rare cases, sildenafil may also cause priapism — prolonged and painful arousal that may last for four hours or longer. Priapism can be a serious emergency, and it’s important to get emergency medical attention as soon as you can to avoid damaging the tissue inside your member.

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Sildenafil 100mg Drug Interactions

Sildenafil and other PDE-5 inhibitor medications can interact with other drugs, including several common medications used to treat chest pain, high blood pressure (sildenafil can cause low blood pressure) and other conditions related to heart health and cardiovascular disease.

Maybe this goes without saying, but do not double up on these medications. That includes using with gas station supplements that don’t have gov approval. Just leave them on the rack when you get your Big Gulp.

In particular, sildenafil can interact with nitrates and alpha-blockers (like doxazosin), potentially causing a severe drop in systolic and diastolic blood pressure that could lead to fainting or serious cardiovascular events such as heart attack or stroke.

As such, you should not take sildenafil or brand name Viagra if you use nitroglycerin or similar prescription organic nitrates, or if you use recreational drugs called “poppers” that contain nitrites such as, amyl nitrite or butyl nitrite.

Medications like ketoconazole, itraconazole and erythromycin will increase the effect of PDE5 medications as well. Weirdly, the same is true of grapefruit juice — it can affect the concentrations of medicine in your body, so you’ll most likely have to avoid it while taking this medication.

Seek medical advice from healthcare professional about any medications you currently take or have recently taken before taking sildenafil, and mention any underlying medical conditions, including:

Heart diseases like angina
Heart problems like pulmonary arterial hypertension or an irregular heartbeat
If you have previously experienced any type of cardiovascular event
A blood disease like leukemia or sickle cell anemia
Peyronie’s disease

The more you can tell your healthcare provider, the better they’ll be able to assess your risk and make sure you’re safe while using sildenafil.

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The Bottom Line on Using Sildenafil 100mg

Intimate activity: the reason we’re all here, in more ways than one. If you’re not having the intercourse you want, sildenafil might be the pathway back.

Sildenafil comes in several dosage forms. Your healthcare provider may prescribe sildenafil at a dosage of 100mg if you have moderate to severe ED, or if you don’t experience any improvements at a lower dosage.

Sildenafil is most effective as an ED treatment when it’s taken at this dosage.
BUT it also has the highest risk of causing side effects.
As such, it’s important to let your healthcare provider know if you experience any issues while using sildenafil to treat ED.
If you do experience adverse effects with sildenafil, you may benefit from using a more selective inhibitor of PDE5, such as avanafil (available as Stendra) Others like tadalafil (Cialis) and vardenafil (Levitra) might be an option as well.

Interested in finding out more before you get started? This guide to the most common treatments for ED goes into more detail about your most effective options, from sildenafil to several other FDA-approved medications for treating ED and having more satisfying intercourse.

This article originally appeared on Hims.com and was syndicated by MediaFeed.org.

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